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In therapeutic doses, no evidence of clinically significant interactions with other commonly used drugs has so far been observed.
However, as with other NSAIDs, caution should be exercised in patients receiving: Oral anticoagulants (eg, coumarins); antihypertensive treatment with thiazide diuretics, ACE inhibitors and β-blockers; methotrexate and lithium and; other pain relievers containing aspirin, ibuprofen or other NSAIDs; oral corticosteroids, SSRI, anti-platelet agents, cardiac glycosides, ciclosporin, mifepristone, tacrolimus, zidovudine, quinolone antibiotics.
